CLINICAL TRIALS AND OBSERVATIONS Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury
نویسندگان
چکیده
1Morehouse School of Medicine, Atlanta, GA; 2Medical University of South Carolina, Charleston; 3American University of Beirut, Beirut, Lebanon; 4Novartis Corporation, East Hanover, NJ; 5University of Toronto, Toronto, ON; 6Children’s Hospital & Research Center Oakland, CA; 7Johns Hopkins University, Baltimore, MD; 8University of Miami, FL; 9Columbia University, New York, NY; 10University of Mississippi Medical Center Children’s Hospital, Jackson; 11Medical College of Georgia, Augusta; 12Children’s Hospital of Philadelphia, PA; 13Children’s Mercy Hospital, Kansas City, MO; 14Children’s Hospital Los Angeles, CA; and 15St Jude Children’s Research Hospital, Memphis, TN
منابع مشابه
Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury.
Chronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overload (STOP and STOP2; n = 271). Most received desferrioxamine chelation. Serum ferritin (SF) changes appeared nonlinear compared with prechelation es...
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R2* magnetic resonance imaging (R2*MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n 32; -thalassemia major, n 6; and bone marrow failure, n 5) were analyzed: median age, 14 years, median transfusion duration, 1...
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Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities including iron overload. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) was a multicenter phase 3 randomized trial comparing standard treatment (transfusions/chelation) to alternative treatment (hydroxyurea/p...
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OBJECTIVE The aim of this study was to determine, using a combination of measures, the prevalence of iron deficiency anaemia (IDA) in children under five years-of-age who have sickle cell disease (SCD) and attend the Sickle Cell Clinic (SCU) of the Tropical Medicine Research Institute. MATERIALS AND METHODS Children with homozygous sickle cell anaemia (Hb SS) or doubly heterozygous for Hb S a...
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In the STOP II trial, discontinuation of prophylactic transfusions in high risk children with sickle cell disease (SCD) resulted in a high rate of reversion to abnormal blood-flow velocities on transcranial Doppler (TCD) ultrasonography and strokes. We analyzed data from STOP II to determine the effect of discontinuing transfusions on the development or progression of silent brain infarcts on m...
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